Brucellosis out-numbered all other reported laboratory-acquired infections and together with tuberculosis, tularemia, typhoid, and streptococcal infection accounted for 72% of all bacteria infections and for 31% of infections caused by all agents. Only one-third of the 1,342 cases cited had been reported in the literature.
PREMIER DIAGNOSTICS LONE MOUNTAIN SERIES
In 1951, Sulkin and Pike( 114 ) published the second of a series of summaries of laboratory-associated infections based on a questionnaire sent to 5,000 laboratories. Known accidents were recorded in 27 (12%) of the reported cases. In at least a third of the cases the probable source of infection was considered to be associated with the handling of infected animals and tissues. In 1949, Sulkin and Pike( 113 ) published the first in a series of surveys of laboratory-associated infections summarizing 222 viral infections-21 of which were fatal. In 1941, Meyer and Eddie( 75 ) published a survey of 74 laboratory-associated brucellosis infections that had occurred in the United States and concluded that the ''handling of cultures or specimens or the inhalation of dust containing Brucella organisms is eminently dangerous to laboratory workers." A number of cases were attributed to carelessness or poor technique in the handling of infectious materials.
Published reports around the turn of the century described laboratory-associated cases of typhoid, cholera, glanders, brucellosis, and tetanus( 123 ). Personnel have contracted infections in the laboratory throughout the history of microbiology. Microbiology laboratories are special, often unique, work environments that may pose special infectious disease risks to persons in or near them.
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